Currently VaxEffect is only available through Health Care Professionals. Please Contact Your Doctor’s Office Today to Learn More.

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Provide
your patients

with the answers they are looking for regarding their immune response to the COVID-19 vaccine or SARS-CoV-2 virus.

The VaxEffect test is highly Sensitive and Specific

in detecting antibodies produced by the COVID-19 vaccine and SARS-CoV-2 virus.

99% Sensitive

99%+

Sensitive

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99%+

Specific

99% Sensitive

99%+

Sensitive

Plus Sign Image
99% Specific

99%+

Specific

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Our technology simultaneously detects antibodies that

target two COVID-19 viral proteins…

Our VaxEffect COVID-19 Vaccine Immune Response Test provides both a qualitative (positive or negative) result and a quantitative (antibody amount) assessment which measures your patient’s immune response to the COVID-19 vaccine or to prior exposure to the SARS-CoV-2 virus.

Nucleocapsid (N) protein

the highly immunogenic

Nucleocapsid (N) protein

The Receptor-Binding Domain (RBD) portion of the Spike (S) protein

the Receptor-Binding Domain (RBD) portion of the Spike (S) protein, which is associated with neutralizing antibodies

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Qualtitative result and quantitative assemsment
Negative Result

A negative result indicates

RBD and NC antibody titer below lowest detection level.

Negative Result

A fully vaccinated individual with a negative VaxEffect result

may benefit from an immune system evaluation, if clinically indicated.

Positive Result

A positive vaccine response

is measured by antibody production to only the Spike protein.

Positive Result

A positive result for prior exposure to SARS-CoV-2 virus

is detected by antibody production to both the Spike and Nucleocapsid viral proteins.

The Value of the VaxEffect Report

The VaxEffect Patient Test Result Page and associated Clinical Laboratory Report provides a comprehensive overview of the patient’s VaxEffect Test results. The VaxEffect Test measures the level of IgG antibodies a patient has generated in response to the COVID-19 vaccine they received, or from prior exposure to this virus.

The patient’s individual results are presented in Boxes 1 – 5.

  • Box 1 indicates if the patient has generated an immune response to the COVID-19 vaccine or from prior exposure to the SARS-CoV-2 virus.
  • Box 2 identifies if that immune response is due to the virus or from the vaccine the patient has received.
  • Box 3 is the VaxEffect Score that provides a quantitative measure of the level of antibodies produced by the patient.
  • Box 4 indicates, as a percentile, a comparison of the patient’s VaxEffect Score to everyone else who has taken the VaxEffect Test.
  • Box 5 tracks the individual’s VaxEffect Score overtime through repeat testing, and plots this in correlation with vaccination and booster administration.

The Value of the VaxEffect Report

Patient Results section reports both the IgG antibody level targeting the Receptor Binding Domain (RBD) epitope found in all US COVID-19 vaccines and the IgG antibody level to the Nucleocapsid (NP) protein present only on the SARS-CoV-2 virus.

Reference Range Section illustrates the cut off values that determines if an antibody response has been generated or not. If the Patient Results for RBD or NC is higher than 1.1, then the patient has generated an antibody response to that viral protein. If the number in the Patient Results is less than 1.1, then the level of antibodies is below detection and is considered borderline (between 0.9 and 1.1) or negative (below 0.9).

A fully vaccinated individual with a negative VaxEffect result (COVID-19 antibody titer was below lowest level of detection) may benefit from an immune system evaluation, if clinically indicated.

The Value of the VaxEffect Report

Box 1 reports if the VaxEffect Test has detected IgG antibodies to either the Receptor Binding Protein (RBD) epitope found in all US COVID-19 vaccines or Nucleocapsid (NC) protein, present only on the SARS-CoV-2 virus.

"Y" indicates an immune response has been generated by the patient in response to either the vaccine they received or to prior exposure to the SARS-CoV-2 virus.

"N" indicates that, at the time of testing, the patient does not have antibodies at the level that can be detected by the VaxEffect Test to either the vaccine they received or to prior exposure to the SARS-CoV-2 virus (whether or not they received the vaccine). "N" does not indicate if the patient ever had antibodies to the virus or vaccine; it can only demonstrate the presence of antibodies at time of testing.

A fully vaccinated individual with a negative VaxEffect result (COVID-19 antibody titer was below lowest level of detection) may benefit from an immune system evaluation, if clinically indicated.

The Value of the VaxEffect Report

Box 2 differentiates if a positive immune response indicated in Box 1 was induced by either prior exposure to the SARS-CoV-2 virus or after the patient received a COVID-19 vaccine.

"Y" indicates that the patient has been previously exposed to the SARS-CoV-2 virus. This is determined by detection of IgG antibodies in the blood sample specific for the nucleocapsid protein found on the SARS-CoV-2 virus, that absent in any of the FDA approved Covid-19 vaccines (under EUA or full approval).

"N" confirms that the immune response the patient has generated is in response to the COVID-19 vaccine they received and that the patient has not been exposed to the virus, or if they had been exposed to the virus previously, the immune response has subsequently declined below lowest level of detection.

The Value of the VaxEffect Report

The VaxEffect Score provides a quantitative IgG antibody measure generated in response to the Receptor Binding Protein (RBD), present in all of the current FDA approved COVID-19 vaccines (EUA or full approval) or the SARS-CoV-2 virus. The higher the score the more antibodies have been generated. VaxEffect Scores range between 1.2 to 33 (highest level detected at current time) for individuals who received a second shot of a vaccine. A third or subsequent booster may increase this range. Antibody levels are known to decline over time so repeat testing to monitor antibody levels to the vaccine received or prior exposure to the SARS-CoV-2 virus is recommended.

If no antibody response is detected, then no VaxEffect Score will be provided in Box 3. A fully vaccinated individual with a negative VaxEffect result (COVID-19 antibody titer was below lowest level of detection) may benefit from an immune system evaluation, if clinically indicated.

The Value of the VaxEffect Report

To better understand the VaxEffect Score as it relates to others who have also taken the VaxEffect Test we provide the patient’s percentile rank. This compares the VaxEffect Score of the patient to everyone else who has taken the test. The value represents the percent of individuals (from 0 to 100) who have VaxEffect Scores that re lower than this patient’s score.

For example, a percentile value of 75 means that the patient has generated antibodies at a level greater than 75% of everyone else who has taken the VaxEffect Test. Although the percentile value does not indicate a relative level of protection, research has shown that relative level of antibodies correlates positively with the ability to either resist a breakthrough infection with SARS-CoV-2 or to lessen the severity of illness (ref: Gilbert et. al.; MedRxiv, Aug. 15th 2021).

If no antibody response is detected, then no percentile rank will be provided in Box 4. A fully vaccinated individual with a negative VaxEffect result (COVID-19 antibody titer was below lowest level of detection) may benefit from an immune system evaluation, if clinically indicated.

The Value of the VaxEffect Report

Patients are encouraged to track their level of antibodies to the COVID-19 vaccine they received or generated in response to prior exposure to the SARS-CoV-2 virus. Box 5 tracks the VaxEffect Scores associated with every test the patient has taken. Changes in immune levels over time will be easily understood and you will be able to quantify the improvement seen after the patient receives a booster shot if clinically recommended. The chart will indicate the date of the last vaccination received plus the date of the booster shot, if received subsequently.

If the patient has not generated an immune response as measured by the VaxEffect Score, this will be shown on the chart as a VaxEffect Score of 0 (zero) and be labelled “BD” (Below Detection).

A fully vaccinated individual with a negative VaxEffect result (COVID-19 antibody titer was below lowest level of detection) may benefit from an immune system evaluation, if clinically indicated.

Patients with Immune Compromised Conditions:

VaxEffect Test Response

The VaxEffect Test is uniquely created to detect weak but positive immune response results due to its wide dynamic range.

VaxEffect Test Fighting

Including those who are fighting cancer, with diabetes, or with auto-immune issues, who may have generated a weak immune response to the vaccine.

VaxEffect Test Vigilance

A medical professional may ask these individuals to remain vigilant in staying safe from virus exposure and consider having a booster shot when available.

The VaxEffect Score.

Simple, Convenient, Accurate.

VaxEffect Score Distribution VaxEffect Score Distribution VaxEffect Score Distribution

The VaxEffect Score is an accurate quantitative measurement of your patient’s personal titer to the COVID-19 vaccine or previous exposure to the SARS-CoV-2 virus.

The VaxEffect Score is calculated by dividing the fluorescence value of an individual test result by the negative cut-off fluorescence value.

The VaxEffect Score will also allow your patients to know their level of antibody response in comparison to others who have taken the test.

Monitoring your patient’s VaxEffect Score over time with repeat testing allows you to determine COVID-19 antibody titer levels and be informed of changes to their immune response with repeat testing.

The VaxEffect Free Covid-19 Vaccine Response Sample Collection Kit The VaxEffect Free Covid-19 Vaccine Response Sample Collection Kit

Request Your Free VaxEffect Blood Sample Collection Kit!

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How It Works

Request free VaxEffect Sample Collection Kits

After kits arrive, please register your patients

Collect and ship patient blood sample
(following kit instructions)

Receive results from VaxEffect
within one to two business days after receipt

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Your VaxEffect Score

Your patient's individual VaxEffect Score does not currently predict immunity but does provide accurate and quantitative measurement of antibody titers generated by COVID-19 vaccination or prior infection.